Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival […] PGRN/GRN is a neurotrophic factor with activities that may be involved in the development of the nervous system and in neurodegeneration […] The full-length precursor, PGRN, exerted similar neurotrophic properties, both in motor and cortical neurons (Fig. 2, E and F). The maximal effect observed was a 38.5 and 22.0% increase in neuronal survival for motor and cortical neurons, respectively. ;Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling. […] ERK1/2 and Akt signaling mediate the neuroprotective activities of PGRN against MPP+ toxicity;Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3ß […] PGRN induces neurite outgrowth in primary cultures of mouse cortical neurons.