In conclusion, Nurr1 overexpression exerts neuroprotective and anti-inflammatory roles via down-regulating CCL2 in both in vivo and in vitro PD models, contributing to developing mechanism-based and neuroprotective strategies against PD.;In the MPP(+)-pretreated PC12 cells, PPARgamma and Nurr1 agonists and their combined form resulted in a decrease in the cell death rate.