In primary DA neurons, rotenone-induced mitochondrial fragmentation and lethality is attenuated as the result of hucp2 expression.;Taken together, our results demonstrate a neuroprotective effect of hUCP2 in DA neurons in a Drosophila sporadic PD model.;The results showed that the expression of UCP2 and UCP5 was significantly elevated in the ischemic lesions compared to the intact area.